Located in Southeast Alabama, Clayton serves as the county seat of Barbour County. The city is named after Augustine S. Clayton, a Georgian congressman. Historically, the town was located at the headwaters of the Pea and Choctawhatchee rivers on this historic road from Hobdy’s Bridge over the Pea River to Eufaula on the Chattahoochee River. The first true settlement was established around 1823. Clayton became the county seat of Barbour County is 1833 and laid out a central courthouse square plan. The first Circuit Court was held in Clayton on September 23, 1833. The Clayton post office was established in September 1835 with John F. Keener as postmaster. The town was incorporated on December 21, 1841 by the Alabama Legislature and was listed as having a population of 200. Its first mayor after incorporation was John Jackson.
Clayton has a rich history with four places listed on the National Register of Historic Places. Clayton is also known for the Whiskey Bottle Tombstone, once featured in Ripley’s Believe it or Not!